Tubular Insufficiency and Renal Dwarfism*

Taken as a whole, growth disorders attributed to various causes: (1) Lack o material, especially proteins; (2) distui neuro-hormonal regulation; (3) disorders bolism, e.g., in absorption in the intesti portation, assimilation or excretion; response of the end-organs, i.e., bone a plasm in general. In this complex syster functions the kidney plays a prominent pa it is not only the organ of elimination metabolites, but, also, in its distal tubuli most important seat (end-organ) of many adjustments. If these adjustments fail th growth suffers in consequence. The regulation of the metabolism sodium chloride, calcium and phosphate and amino-acids, depends on the int certain mechanisms (Fig. 1).